Holger Bastians) at the Department of Cellular Oncology of the Georg-
August University Göttingen is part of the Göttingen Comprehensive
Cancer Center (G-CCC) and part of the Göttingen Center für Molecular
Biosciences (GZMB) and is seeking excellent candidates for
postdoctoral and pre-doctoral positions (Ph.D.).
Our lab is focussing on the molecular mechanisms of cell division in
human cancer cells. Especially, we are focussing on mitosis and its
associated signalling pathways and their role in chromosome
segregation and thus, their importance for
the maintenance of chromosomal stability.
In particular, we aim to define the genetic lesions that are
responsible for the chromosomal instability (CIN) and aneuploidy
phenotype in human cancer, which represents a major characteristic of
human cancer and which is involved in tumorigenesis, tumor progression
and therapy resistance.
Possible projects include the analyses of the mechanisms of how a
given somatic cell can be transformed into a cell exhibiting the
chromosomal instability pheneotype and how chromosomal instability can
mediate resistance towards chemotherapeutic treatment. From these
basic cell biological questions we would also like to go further and
to identify and characterize novel therapeutic targets that can be
exploited to taget chromosomal instable tumor cells.
To address these goals we employ a wide variety of modern and state-
of-art techniques including human tissue culture,
transfection/infection, siRNA/shRNA, biochemical assays, and in
particular different microscopic techniques including deconvolution
and confocal imaging as well as life-cell microscopy in order to
follow living cells that undergo mitotic cell division.
More detailed information about our research focus can be found on the
website: http://www.uni-goettingen.de/en/216801.html and please refer
to our most recent publications of original articles (e.g. published
in Nature Cell Biology and Cancer Research) and in our most recent
review articles:
Stolz, A., Ertych, N., Kienitz, A., Vogel, C., Schneider, V., Fritz,
B., Jacob, R., Dittmar, G., Weichert, W., Petersen, I. und Bastians,
H. (2010). The CHK2-BRCA1 tumor suppressor pathway ensures chromosomal
stability in human somatic cells. Nature Cell Biology 12: 492 – 499.
Stolz, A., Vogel, C., Schneider, V., Ertych, N., Kienitz, A., Yu.H.
und Bastians, H. (2009). Pharmacologic abrogation of the mitotic
spindle checkpoint by an indolocarbazole discovered by cellular
screening efficiently kills cancer cells. Cancer Research, 69: 3874 -
3883.
Reviews:
Stolz A, Ertych N, Bastians H. (2010). Tumor suppressor CHK2:
regulator of DNA damage response and mediator of chromosomal
stability. Clin Cancer Res. 17(3):401-
Kaestner P, Bastians H. (2010). Mitotic drug targets. J. Cell Biochem.
111(2):258-65.
The ideal candicate for a pre- or postdoctoral position in our lab
should possess the ability to work in a highly competitive field of
science. A high motivation and enjoying to work in a team is a must.
Candidates for PhD doctorates will be given the chance to become part
of the Göttingen Graduate School for Neurosciences and Molecular
Bioscineces (GGNB), one of the most prestigous graduate schools in
Germany funded by the German Excellence Initiative.
Please send your complete application (perferred as email attachments)
including CV, brief summary of the research experience and interests
and at least two names of referees who agreed to be contacted to:
Holger Bastians, Email: holger.bastians@uni-goettingen.de