research lab
(TV-L E13/2 - Projects funded by the Deutsche Forschungsgemeinschaft (DFG); 3 years - extension possible)
available
- to study cytoskeletal and synaptic cytomatrix structures in neuronal development and synaptic function and plasticity.
- to study protein interactions and functions of members of the syndapin family (F-BAR proteins)
- to characterize novel cellular effector proteins involved in cytoskeletal and/or membrane (transport) processes
- to study osmotic stress responses of the cortical actin cytoskeleton at both the cell biological and the molecular level
The Institute for Biochemistry I at the FSU Jena provides a stimulating research environment with excellent technical equipment in a recently completely reconstructed building right in the centre of Jena - one of the top-ranking and most lively biotech cities of Germany (ranked 2nd in the career atlas of all German cities – right behind Munich!).
The aim of our internationally well-known research team is to gain a molecular understanding of how the cortical actin cytoskeleton and specialized cytomatrix structures underlying the plasma membrane contributes to development, plasticity and function of cells and cellular networks, such as those formed by neurons in the brain.
We are currently studying several molecular players at the membrane/actin interface and are characterizing their role in both cytoskeletal and membrane dynamics (for work of our PhD students e.g. see Ahuja et al., 2007 Cell; Dharmalingam et al., 2009 J. Neurosci.; Schwintzer et al., 2011 EMBO J.).
We are seeking productive additions to our team
- for generation and phenotypical analyses of KO-animals (several already available),
- for studying membrane and actin dynamics in cell lines, in primary neuronal cultures, and in tissue sections and
- for molecular/mechanistic studies e.g. using in vitro reconstitutions of actin dynamics and of membrane interactions and modulations, respectively.
Applicants should have a solid theoretical and practical knowledge of modern cell and/or neurobiology and experience in the generation and analyses of KO mice, in advanced methods of microscopy and/or in the biochemical and biophysical methods required for studying actin cytoskeletal dynamics and membrane interactions both in vitro and in vivo.
Candidates need to be distinguished by a high motivation to succeed in science and to work independently. However, it is also crucial to integrate into our team smoothly and to be a kind, efficient and reliable team-player.
Starting date is flexible. Due to the internationality of both our group and life in the young and vibrant university town Jena, knowledge of the german language is not required but fluent English is a prerequisite.
For further information please also see our webpage (http://www.biochemie.uniklinikum-jena.de/Biochemie+I/Stellenangebote.html).
Please send your complete application (incl. 2-3 ref. addresses) to
Prof. Dr. Britta Qualmann & Prov. Doz. Dr. Michael M. Kessels
britta.qualmann@mti.uni-jena.de
Methoden:
Applicants should have a solid theoretical and practical knowledge of modern cell and/or neurobiology and experience in the generation and analyses of KO mice, in advanced methods of microscopy and/or in the biochemical and biophysical methods required for studying actin cytoskeletal dynamics and membrane interactions both in vitro and in vivo.
Anfangsdatum: 1. Oktober 2011
geschätzte Dauer: 3-4 Jahre
Bezahlung: TV-L 1/2 E13
Veröffentlichungen:
for work of our PhD students e.g. see
Ahuja et al. 2007 Cell
Haeckel et al. 2008 J. Neurosci.
Dharmalingam et al. 2009 J. Neurosci.; Schwintzer et al. 2011 EMBO J.
Homepage: http://www.biochemie.uniklinikum-jena.de/Biochemie+I/Stellenangebote.html
Starting date is flexible