Organisation unit:
Epidemiology, Biostatistics and HTA
The Department of Epidemiology, Biostatistics and HTA is an expert centre for research methodology for the health sciences. Its research program in the domains of cancer, reproduction and complex interventions serves as basis for academic teaching, training of Master and PhD students, and consultancy for clinical researchers.
Job profile:
In recent years, single-nucleotide polymorphisms and other genetic variants associated with cancer development have been identified. Our team has participated in several genome-wide association studies and we have identified several genetic variants that are associated with the development of human urinary bladder cancer (UBC)(1-4). A key question is how these variants affect cellular processes (e.g. gene transcription and protein function), and contribute to carcinogenesis. To answer these questions, we want to predict (using bioinformatics) the impact of the variants on gene transcription, RNA splicing, protein sequence etc. Functional studies will address the expression and function of genes and gene products in which the genetic variation has been introduced. In addition, we will correlate the genotypes of the identified variants with gene expression in normal human bladder specimens, using transcriptomic and eQTN analysis.
For this project, we are looking for an ambitious junior researcher. During the project, the PhD student will be responsible for the planning, organization and the execution of the experiments. He/she will communicate the results to the supervisors, present data on international meetings, and write scientific papers. This four-year project should culminate in a PhD thesis.
1, Kiemeney LA et al. Nat Genet. 2008; 40:1307-12 ; 2, Rafnar T et al. Nat Genet. 2009; 41:221-7; 3, Kiemeney LA et al. Nat Genet. 2010; 42:415-9; 4, Rafnar T et al. Hum Mol Genet. 2011; Jul 12.[Epub ahead of print].
Requirements:
Masters degree in (Medical) Biology, Molecular Life Sciences or related discipline. Experience with molecular & cellular biology; interest in bioinformatics. We highly appreciate the general competencies Radboud University Nijmegen Medical Centre for all employees: customer directed, integrity, co-operate and self-management.
• An independent and well-structured working style, demanding high quality of your own work
• Well-developed social skills directed to work in a team, excellent interpersonal and communicative skills
• Strong motivation to succeed in scientific research
• Interested to work abroad
• Excellent presentation and scientific writing skills
Terms of employment:
• Temporary 4 years
• 36 hrs per week
• Salary level 10A: maximal € 2700 gross per month
Information :
Dr. G.W. Verhaegh, senior researcher, (024) 3610510
Prof. dr. L.A.L.M. Kiemeney, full professor, (024) 3613745
Application:
Preferably on line via: www.umcn.nl
Written applications including CV to:
UMC St Radboud
Mw. M.I. Jans, HRM counselor
Huispostcode 155
Concerns vacancy: 010715
Postbus 9101
6500 HB Nijmegen