Molecular mechanisms leading to a distortion of hormonal regulation and energy imbalance as a result of selection and excessive energy supply in the Berlin Fat Mouse line: In this project, the target region will be further fine mapped and candidate genes will be functionally analyzed by gene targeting using IPS cells.
PhD position: A. Schürmann Glucose & energy homeostasis
Regulation of whole-body glucose and energy homeostasis: We are looking for a motivated and skilful PhD student with a BSc/MSc in biology, biochemistry or nutritional science who is interested in the pathophysiolgy of type 2 diabetes. In the early stages of type 2 diabetes, pancreatic beta-cells adapt to insulin resistance by increasing mass and function. As nutrient excess persists, hyperglycemia and elevated free fatty acids negatively impact beta-cell function. We are studying the molecular bases of lipoglucotoxicity which finally results in beta-cell failure.
PhD position: H. Krude: Epigenetic regulation of body weight & metabolism
Epigenetic regulation of body weight and metabolism: We are looking for a motivated PHD student with a BSc/MSc in biological science. Our research is focussed on the epigenetic regulation of body weight within the hypothalamus.
The MD positions can be linked to any subproject of the programme
2 qualifying scholarships
DFG-funded and associated teams participating in this training, teaching and research network are located at the Charité (www.charite..de/) Campus CBF, CCM or CVK, of the Humboldt and the Free University, the German Institute of Human Nutrition, Rehbrücke (DIfE; www.dife.de) and the Max Delbrück Center for Molecular Medicine, Berlin Buch (MDC; http://www.mdc-berlin.de).
Methoden:
The interdisciplinary research, study and training program in English language comprises molecular, cellular & clinical endocrinology, pediatric & developmental endocrinology, endocrine epidemiology & pharmacology, genetics, nutrition and metabolism research.
The central idea of this program is to connect research on hormonally regulated processes of differentiation and adaptation to changing requirements of nutrition, environment, and exogenous factors including therapy. Mutual interactions between fine-tuned differentiation-dependent, age-adapted and disease-associated hormonal networks will be examined. To achieve these aims, the introduction of new model organisms and innovative methods and the application of established research principles and procedures of hormone research are required. Novel techniques and tools of molecular biology, genetics, biostatistics, and approaches involving meta-analysis of research data will be employed.
Anfangsdatum: 1. Oktober 2011
geschätzte Dauer: 3 Ph.D. 36 M, 2 qualifying scholarship 12 M, 3 MD 12 M
Bezahlung: Scholarships
Homepage: http://www.endogk.de/
Additionally to the 3 PhD scholarships, 2 qualifying scholarships will be available, providing the chance to prepare and train for the PhD track within 12 months. We look for applicants preferentially under 28 years of age with excellent, above-average qualifications in life sciences or medicine. The structured training program for PhD doctoral students aims for academic grades in 3 years, for MD students in 1 year. For detailed information on projects and curriculum, please visit our web page of the GRK 1208 (http://www.endogk.de/). Deadline for applications is August 31, 2011. Please indicate your project priorities, and send your application as one pdf file (including CV, credentials, certificates, 2 letters of recommendation, synopsis of diploma/master thesis), to the coordinator’s office. Contact: Prof. Dr. J. Köhrle (coordinator: Mrs. Angelika Althaus), e-mail: angelika.althaus@charite.de