Postdoctoral Researcher Toxicogenomics
Universiteit Maastricht
Location: Maastricht (The Netherlands)
Available from: 2010-12-28
Organisation type: education, research
Language requirements: EN (good)
Job type: full-time
Category: Biology
Clinical
Chemistry
Medical
Education: PhD, M.D.
Post-doc “Safety and environmental impact of chemicals and bio-based molecules and processes”, part of the Bio-BAsed Sustainable Industrial Chemistry (B(E)-BASIC) project
You will be appointed as a post-doc on the project “Safety and environmental impact of chemicals and bio-based molecules and processes”, part of the Bio-BAsed Sustainable Industrial Chemistry (B(E)-BASIC) project. The general aim is to develop alternative, high-throughput in vitro screens for the chronic rodent toxicity assay with the focus on hepatotoxicity. The project also includes an international collaboration for the use of database information available to forecast potential chemical toxicity in humans. The objective is to develop a liver-based reporter gene sets for carcinogenicity/genotoxicity prediction enabling safety evaluations of novel biobased industrial compounds. In collaboration with a technician, the effect of a selection of compounds on the whole genome gene expression will be analyzed by microarray techniques, and combined with phenotypical endpoints. Your main contribution will be the application of advanced integrative bioinformatics and biostatistics for statistical analysis, pathway analysis and class discrimination.
You will be supervised by Prof. Dr. Jos Kleinjans and Dr. Jacco Briedé.
Requirements
We are looking for a creative scientist with a Dr’s degree in (bio)chemical/biomedical sciences and a strong background in molecular biology, biostatistics and bioinformatics, who wants to run this project. Experience or great affinity with analysis of data-base stored information and application of transcriptomic analysis tools is important, as well as good communication skills to operate in an international team of scientists.
Labour conditions
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website http://www.maastrichtuniversity.nl/ , A-Z Terms of Employment.
Contract
Temporary
until 31-12-2014
Maastricht University is renowned for its unique, innovative, problem-based learning system, which is characterized by a small-scale and student-oriented approach. Research at UM is characterized by a multidisciplinary and thematic approach, and is concentrated in research institutes and schools. Maastricht University has around 14,000 students and 3,500 employees. Reflecting the university’s strong international profile, a fair amount of both students and staff are from abroad. The university hosts 6 faculties: Faculty of Health, Medicine and Life Sciences, Faculty of Law, School of Business and Economics, Faculty of Humanities and Sciences, Faculty of Arts and Social Sciences, Faculty of Psychology and Neuroscience.
Department
NUTRIM School for Nutrition, Toxicology and Metabolism
NUTRIM initiates and catalyzes translational research into nutritional health benefits and risks focusing on metabolic and chronic inflammatory diseases. Through its research master and PhD program NUTRIM aims to educate scientists of high academic excellence and ambassadors to support and develop the filed of nutrition, metabolism and toxicology within and outside the Netherlands. 16 Biomedical, clinical, and behavioural-science departments are incorporated within NUTRIM. The school participates in the Graduate School VLAG (Food Technology, Agrobiotechnology, Nutrition and Health Sciences), accredited by the Royal Academy of Arts and Sciences (KNAW) is a partner in TI Food and Nutrition and participates in TI-Pharma and the Centre for Translational Molecular Medicine. These unique consortia of government, industry and research aim to stimulate the transfer of knowledge generated in fundamental research to Dutch industry and thus to strengthen its innovative power and competitive strength.
Additional information
Dr. J.J. Briedé, T: +31-43-3881094, email: j.briede@grat.unimaas.nl
Department of Health Risk Analysis and Toxicology www.grat.unimaas.nl